Cushing's syndrome

Also called hypercortisolism.  A disorder affecting the adrenal gland or pituitary gland, causing an overproduction of the hormone cortisol.  This results in a tendency to gain weight, especially on the face, which develops a typical moonlike appearance, the abdomen, neck, and upper back, which develops a buffalo hump.  Symptoms also include thinning  and weakness of the upper arms and upper legs, thinning of the skin with easy bruising and pink or purple stretch marks (striae) on the abdomen, thighs, breasts, and shoulders, increased acne, facial hair growth, a ruddy complexion, and often a skin darkening (acanthosis) on the neck.  Children show obesity and poor growth in height, fatigue, weakness, depression, mood swings, increased thirst and urination.  Treatment includes drugs and/or surgery.